CLSI M38-A3 testing covered 216 Taiwanese clinical and environmental isolates: 205 Scedosporium and 11 Lomentospora prolificans. L. prolificans was pan-resistant to tested agents except olorofim, while olorofim had MIC90 values at or below 0.12 mg/L across taxa. Most MIC variability, 72.5-89.2%, occurred within rather than between species, limiting species identity as a susceptibility proxy and supporting isolate-level testing.
Key findings
- Olorofim MIC90 was
Why this matters globally
The in vitro results support olorofim against difficult resistant moulds and favor direct testing over species-based assumptions, but do not establish patient outcomes.
Thai researcher contribution
A Mahidol-Oxford Tropical Medicine-affiliated researcher contributes medical-mycology expertise to the Taiwanese dataset.
Limitations to consider
These are in vitro MICs from one country, with only 11 L. prolificans isolates and no clinical breakpoint or patient-efficacy evidence in this study.
Verify the original sources
Journal of Antimicrobial ChemotherapyJournal of Antimicrobial Chemotherapy↗DOI: 10.1093/jac/dkag236