Linked Manitoba data from 1984-2023 compared 12,639 people with IBD with 126,180 matched controls. Dialysis occurred in 1.48% versus 0.82% and kidney transplantation in 0.25% versus 0.10%. IBD remained associated with ESRD (adjusted HR 1.53), with a stronger estimate for Crohn’s disease than ulcerative colitis. Diabetes, hypertension and heart failure remained major predictors; treatment and surgery associations may reflect disease severity rather than causal harm.
Key findings
- Dialysis and transplantation were more frequent in IBD. • IBD was associated with ESRD at an adjusted HR of 1.53. • Traditional comorbidities remained powerful predictors.
Why this matters globally
The results support long-term renal monitoring in IBD, especially with comorbidities, but do not justify changing medication or surgery solely from observational associations.
Thai researcher contribution
A Siriraj Hospital and Mahidol University-affiliated researcher contributes to a large international population cohort.
Limitations to consider
Claims-based ESRD, retrospective data, residual confounding and confounding by indication limit causal interpretation.
Verify the original sources
Alimentary Pharmacology & TherapeuticsAlimentary Pharmacology & Therapeutics↗DOI: 10.1111/apt.70845