Mn-Ti bimetallic MOF was incorporated into electrospun polyacrylonitrile nanofibers to generate localized electric fields under mechanical stimulation. Ultrasound produced a reported 0.35-V output, accompanied by alternating fields, tumor-cell apoptosis and good compatibility with normal cells. In vivo experiments suppressed glioblastoma growth. The concept remains preclinical and requires long-term implant safety and treatment-control studies.
Key findings
- Ultrasound stimulation generated a 0.35-V output. • The fields were associated with tumor-cell apoptosis and death. • The material suppressed glioblastoma growth in vivo.
Why this matters globally
Localized self-powered fields could overcome limitations of externally wired TTF systems, but translation requires rigorous implant, degradation and field-uniformity evaluation.
Thai researcher contribution
A Chulalongkorn University-affiliated researcher contributes to interdisciplinary biomaterials research for brain-cancer therapy.
Limitations to consider
Evidence is limited to cells and animals; group sizes, follow-up and controls are not fully stated in the abstract, and long-term brain safety is unknown.