Information from the abstract
Litsea elliptica Blume (syn. Litsea petiolata Hook.f.) is traditionally used in Southeast Asia for the treatment of various ailments and has been reported to possess antioxidant and chemopreventive properties. This study investigated the effects of solvent polarity on extraction yield, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity, and cytotoxicity of L. elliptica leaf extracts. Dried leaves were extracted using water, ethanol, and methanol. TPC and TFC were determined using the Folin–Ciocalteu and aluminium chloride colorimetric methods, respectively. Antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays, while cytotoxicity was assessed against HCT116 human colorectal carcinoma and Vero cells using the NR assay. Results exhibited that the ethanol extract exhibited the highest TPC (322.9 ± 3.7 mg GAE/g extract) and TFC (126.8 ± 0.8 mg QE/g extract). The ethanol extract also demonstrated the strongest antioxidant activity, with IC₅₀ values of 14.9 ± 0.5 µg/mL and 2.6 ± 0.1 µg/mL in the DPPH and ABTS assays, respectively. Strong inverse correlations were observed between TPC/TFC and antioxidant IC₅₀ values. The methanolic and aqueous extracts showed comparable cytotoxic activity against HCT116 cells, with IC₅₀ values of 41.01 ± 9.79 and 42.98 ± 6.85 µg/mL, respectively. Notably, the aqueous extract demonstrated the highest selectivity toward HCT116 cells (SI = 8.42). Overall, these findings demonstrate that solvent polarity significantly influences the phytochemical composition and biological activities of L. elliptica leaf extracts and highlight their potential as a natural source of antioxidant and anticancer compounds for further therapeutic investigation.
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Related topics: Traditional and Medicinal Uses of Annonaceae · Phytochemical compounds biological activities · Phytochemicals and Antioxidant Activities
Thai researcher and institutional participation
Kwanchayanawish Machana · Anusorn Thumpithak · Sirirat Phakpaknam · Pattarakorn Sirikul · Pornpimol Namvichaisirikul · Atcharee Chatsuwankit · Nitcha Prapruttipong · Wuttipat Kumpiranont · Kanokwan Waiyanont · Atthasit Sangthong · Natcha Namsiripongpun · Chonlada Judprakob · Natthida Weerapreeyakul · Maharat Nakhon Ratchasima Hospital · Nakhon Ratchasima Rajabhat University · Burapha University · Suan Sunandha Rajabhat University · Khon Kaen University
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