Information from the abstract
Elizabethkingia species have emerged as important nosocomial pathogens associated with multidrug resistance and persistent infections. This study aimed to characterize clinical Elizabethkingia isolates from Northern Thailand regarding antimicrobial susceptibility, virulence-associated phenotypes, and biofilm formation, and to evaluate the antimicrobial and anti-biofilm activity of dialdehyde cellulose (DAC) film. A total of 49 clinical isolates were identified by MALDI-TOF mass spectrometry, with species identification confirmed by 16S rRNA gene sequencing. Antimicrobial susceptibility was determined against 12 agents. Virulence traits (protease, lipase, lecithinase, and hemolysin production) and biofilm formation were assessed using standard phenotypic assays. DAC films were evaluated against selected resistant isolates. Elizabethkingia anophelis predominated, and most isolates exhibited multidrug or extensive drug resistance, with high resistance to carbapenems and cephalosporins. Piperacillin–tazobactam, levofloxacin, and trimethoprim–sulfamethoxazole showed the greatest activity. All isolates demonstrated protease production and time-dependent hemolysis, while lipase and lecithinase activities were absent. Biofilm formation varied among isolates, while DAC films inhibited bacterial growth and prevented detectable biofilm formation in the tested isolates. No significant difference was observed between DAC and DAC supplemented with meropenem in inhibition zone diameters (p = 0.555). Clinical Elizabethkingia isolates demonstrated extensive antimicrobial resistance with conserved virulence traits and heterogeneous biofilm formation. DAC films demonstrated antimicrobial activity and prevented detectable biofilm formation under the experimental conditions. Further studies are warranted to evaluate their mechanism of action and potential applications.
Why this record is monitored
This record has an Impact Signal of 75/100 based on recency, source, collaboration, and bibliographic signals. It prioritizes monitoring and is not a judgment of research quality.
Related topics: Infections and bacterial resistance · Infectious Disease Case Reports and Treatments · Veterinary medicine and infectious diseases
Thai researcher and institutional participation
Sastra Yuantrakul · Orathai Yinsai · Tanpong Chaiwarit · Punnaporn Srisithan · Wenting Zhou · Kritsana Ruenjai · Phadungkiat Khamnoi · Kwanjit Duangsonk · Chiang Mai University · Maharaj Nakorn Chiang Mai Hospital
Data limitations
This page is a bibliographic record based on abstract-level information, not a full analysis or quality assessment. Verify the DOI and original article before citation.