Information from the abstract
Acute Hepatopancreatic Necrosis Disease (AHPND) is one of the main culprits for massive shrimp mortality in the aquaculture industry. AHPND is caused by Vibrio parahaemolyticus (VP AHPND ) containing plasmids for the PirA and PirB binary toxins. These toxins cause sloughing and cell death in the hepatopancreatic tubules as well as inflammation in the shrimp gastrointestinal tract. Nevertheless, changes in the pro- and anti-inflammatory signaling molecules have yet to be reported. Here, we examined changes in eicosanoid biosynthesis in the Litopenaeus vannamei gastrointestinal tract infected with VP AHPND isolate 5HP. At 24 h post-infection, cyclooxygenase enzyme levels increased in the hepatopancreases of VP AHPND -infected shrimp. The transcription levels of cytosolic phospholipase A2 were elevated in the intestines of VP AHPND -infected shrimp compared with control shrimp. Although the eicosanoid and PUFA profiles were differentially altered in shrimp hepatopancreas, stomach, and intestines, the levels of prostaglandin F 2α were elevated, whereas the levels of 5-hydroxyeicosapentaenoic acid and 5-hydroxyeicosatetraenoic acid were suppressed in all three organs of VP AHPND -infected shrimp. These findings suggest that eicosanoid changes may serve as biomarkers for shrimp gastrointestinal health. Moreover, they indicate the conserved nature of the eicosanoid biosynthesis pathway in the host-pathogen response to bacterial infection in crustaceans.
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Related topics: Invertebrate Immune Response Mechanisms · Crustacean biology and ecology · Aquaculture Nutrition and Growth
Thai researcher and institutional participation
Wananit Wimuttisuk · Pisut Yotbuntueng · Pacharawan Deenarn · Punsa Tobwor · Surasak Jiemsup · Suganya Yongkiettrakul · Kamonluk Kittiwongpukdee · Siriwan Khidprasert · Chanadda Kasamechotchung · Kitlada Srichomthong · Phawit Putprasert · National Science and Technology Development Agency · National Center for Genetic Engineering and Biotechnology · Mahidol University · Rajamangala University of Technology Tawan-ok · Thammasat University
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