Information from the abstract
BACKGROUND: Acute coronary thrombosis without atherosclerosis may mimic myopericarditis, particularly in young patients. CASE SUMMARY: , and high-sensitivity troponin T increased from 18.6 to 1,151 ng/L. Echocardiography demonstrated regional wall motion abnormalities in the left anterior descending territory. Coronary angiography revealed a proximal left anterior descending intraluminal thrombus causing severe narrowing without underlying atherosclerosis. Conservative management with anticoagulation and dual antiplatelet therapy was initiated. Repeat angiography after 3 days showed complete thrombus resolution with no residual stenosis. Further evaluation revealed marked thrombocytosis and a JAK2 V617F mutation, confirming essential thrombocythemia. DISCUSSION: This case highlights a mechanism-based approach to myopericarditis-like presentations. JAK2-positive essential thrombocythemia represents a plausible prothrombotic contributor after the exclusion of common causes of coronary artery disease in very young patients. TAKE-HOME MESSAGE: Dynamic regional electrocardiogram changes, rapid troponin elevation, and regional wall motion abnormalities should prompt coronary evaluation despite pleuritic symptoms.
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Related topics: Myeloproliferative Neoplasms: Diagnosis and Treatment · Platelet Disorders and Treatments · Vasculitis and related conditions
Thai researcher and institutional participation
Paisit Kosum · Akenarong Pipatputthapong · Pongpun Jittham · Nattakorn Songsirisuk · Peerapon Wong · Rawisut Deoisares · Koravich Phumviwattanasirikul · Worathon Banlue · Nonthikorn Theerasuwipakorn · Chalinee Pravarnpat · Naresuan University Hospital · Naresuan University · King Chulalongkorn Memorial Hospital
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