Extemporaneous dual-drug-loaded contact lenses containing ceftazidime and cefazolin for perforated bacterial keratitis

Information from the abstract

Perforated bacterial keratitis requires intensive topical antibiotic administration combined with bandage contact lens placement and cyanoacrylate glue application, yet conventional eye drops suffer from poor ocular retention and low bioavailability. For this reason, this study developed extemporaneous dual-drug-loaded therapeutic contact lenses containing ceftazidime and cefazolin using two commercial contact lenses of Biomedic ® 1 day Plus (Ocufilcon D; poly(2-hydroxyethyl methacrylate)/methacrylic acid, pHEMA/MAA) and Precision 1 ® 1-Day (Verofilcon A; silicone hydrogel). Using a simple soaking method, the Biomedic lenses exhibited markedly higher loading capacities (up to ~ 40–45 mg per lens) and adsorption efficiencies (~ 50–60%) compared with Precision lenses (< 20 mg; 80% transmittance), indicating suitability for therapeutic wear. In vitro release studies revealed biphasic kinetics with an initial burst followed by sustained diffusion-controlled release, with Biomedic lenses showed more prolonged release than the Precision 1 lenses. Conclusively, the developed system, especially the dual-drug-loaded Biomedic lenses, could represent a promising localized drug-delivery strategy to enhance ocular residence time, reduce dosing frequency, and improve management of perforated bacterial keratitis.

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Related topics: Ocular Surface and Contact Lens · Ocular Infections and Treatments · Advanced Drug Delivery Systems