Information from the abstract
Feline infectious peritonitis (FIP) is a highly fatal disease caused by feline coronavirus (FCoV). Although the acute clinical efficacy of molnupiravir as first-line therapy has been recognized, there are limited data regarding the long-term durability of clinical outcomes and safety profile posttreatment. This retrospective study aimed to evaluate the acute response (weeks 0–12) and long-term clinicopathological outcomes (up to week 40) in cats with naturally occurring effusive FIP treated with molnupiravir. Forty-two cats were included. They received a median molnupiravir dose of 14.3 mg/kg twice daily for at least 84 days (12 weeks). Molnupiravir treatment rapidly resolved clinical signs and effusions (median 7 days). Moreover, significant improvements in white blood cell and neutrophil counts were observed within the first week ( p < 0.05). A transient elevation in alanine aminotransferase levels occurred initially but completely normalized by week 7 without requiring treatment discontinuation. Importantly, paired analysis between posttreatment (week 12) and long-term follow-up (week 40) data revealed no significant deviations in hematological parameters (e.g., hematocrit and lymphocytes) or renal function (creatinine) ( p > 0.05), indicating sustained physiological stability. In summary, molnupiravir is highly effective and safe as first-line treatment for effusive FIP. The transient nature of hepatic enzyme elevation and long-term hematological and renal stability provide strong clinical assurance for its long-term safety profile and the potential for a sustained clinical cure.
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Related topics: Animal Virus Infections Studies · SARS-CoV-2 and COVID-19 Research · Virus-based gene therapy research
Thai researcher and institutional participation
Thiti Surakitkoson · Phuttipan Channgam · Walasinee Sakcamduang · Jeerawat Soonthornsit · Rungrote Osathanon · Mahidol University
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