Information from the abstract
Curcuminoids from Curcuma longa L. have exhibited antiviral activity against several human viruses; however, their comparative efficacy against animal coronaviruses remains unclear. This study evaluated the antiviral and virucidal effects of curcumin (CUR), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), a curcuminoid-rich extract (CRE), and its solid dispersion (CRE-SD) against porcine epidemic diarrhoea virus (PEDV) and feline infectious peritonitis virus (FIPV). Against PEDV, all compounds exhibited multi-stage antiviral activity, confirmed by cytopathic effect reduction, IPMA, and RT-qPCR. DMC was the most consistently potent (EC50 = 0.48–0.98 µg/mL), followed by BDMC and CUR (0.37–4.47, and 1.50–1.99 µg/mL, respectively), while only BDMC lacked prophylactic activity. Purified curcuminoids showed limited activity against FIPV, though this virus remained susceptible to the extract formulations. Molecular docking supported the experimental findings. Notably, CRE and CRE-SD exerted strong virucidal activity against both viruses, suggesting synergistic effects of multiple constituents. These findings highlight curcuminoid formulations as promising veterinary antivirals and disinfectants.
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Related topics: Animal Virus Infections Studies · Veterinary medicine and infectious diseases · Coccidia and coccidiosis research
Thai researcher and institutional participation
Nantawan Deeprom · Natjira Mana · Pharkphoom Panichayupakaranant · Manakorn Sukmak · Ploypailin Semkum · Porntippa Lekcharoensuk · Sirin Theerawatanasirikul · Kasetsart University · Prince of Songkla University
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