Information from the abstract
OBJECTIVE: In monochorionic diamniotic twins with selective fetal growth restriction (sFGR), the Gratacós type is defined by one vessel in one fetus. We asked how much cerebral, venous and myocardial divergence between co-twins it captures. METHOD: Single-center combined retrospective-prospective cohort; one diagnostic examination per pregnancy. Six larger-minus-smaller contrasts were estimated by mixed-effects models on outcome-specific complete pairs. Observed-profile likelihood characterized type-specific phenotypes; HC3 models, bootstrapping and Holm/Benjamini-Hochberg correction tested between-type differences and determinants. RESULTS: Eighty-two pregnancies were included (type I, 27; II, 51; III, 4). The larger co-twin had higher MCA-PI and biventricular MPI and lower MCA-PSV and DV-PIV (all Holm p ≤ 0.006). A coordinated arterial-venous and biventricular profile characterized type II/III alone, yet between-type separation was confined to MCA-PI (1.19 z; 95% CI 0.49-1.88; Holm p = 0.009); neither MPI contrast survived correction. Weight discordance tracked MCA-PSV asymmetry (-0.14 MoM per 10%; Holm p = 0.018), and type modified DV-PIV asymmetry across gestational age (-1.25 z per 2 weeks; Holm p = 0.017), retained excluding type III. CONCLUSION: Umbilical-artery type is mirrored principally by cerebral redistribution. Myocardial alteration is present, including in the larger co-twin, but did not separate types at this sample size, remaining a research phenotype.
Why this record is monitored
This record has an Impact Signal of 72/100 based on recency, source, collaboration, and bibliographic signals. It prioritizes monitoring and is not a judgment of research quality.
Related topics: Assisted Reproductive Technology and Twin Pregnancy · Pregnancy and preeclampsia studies · Fetal and Pediatric Neurological Disorders
Thai researcher and institutional participation
Tanchanok Auwattanamongkol · Nisarat Phithakwatchara · Katika Nawapun · Sommai Viboonchart · Suparat Jaingam · Kanokwaroon Watananirun · Sriwipa Kaewsrinual · Tuangsit Wataganara · Siriraj Hospital · Mahidol University
Data limitations
This page is a bibliographic record based on abstract-level information, not a full analysis or quality assessment. Verify the DOI and original article before citation.