Information from the abstract
ABSTRACT Cold atmospheric plasma (CAP) therapy has emerged as a promising therapy for wound healing. This study aimed to evaluate the feasibility, safety and efficacy of adjunctive CAP therapy for early tracheostomy wound healing compared with standard wound care (SWC) alone. This single‐centre, parallel‐group pilot randomised controlled trial (1:1 allocation) enrolled critically ill patients undergoing tracheostomy. Patients received 1‐min CAP applications on postoperative days 1, 3 and 5 plus SWC or SWC alone. The primary endpoint was the percentage reduction in tracheostomy wound area through postoperative day 7, assessed by a blinded outcome assessor. Due to the nature of the intervention, blinding of participants and treating clinicians was not feasible; however, the outcome assessor was blinded to group allocation. Wound healing trajectories were analysed using linear mixed‐effects models adjusted for baseline wound area. Forty‐two patients were included (CAP, n = 21; SWC, n = 21), with comparable baseline characteristics. By postoperative day 7, wound area reduction was greater in the CAP group than in the SWC group (30.3% vs. 23.6%, p = 0.15). Estimated wound area decreased by 0.08 versus 0.06 cm 2 /day (95% CI 0.06–0.10 and 0.04–0.08, respectively; p = 0.17). No treatment‐related adverse events were observed. Adjunctive CAP therapy was feasible, safe and demonstrated a non‐significant trend towards improved early tracheostomy wound healing. These findings support further evaluation in larger, adequately powered trials.
Why this record is monitored
This record has an Impact Signal of 77/100 based on recency, source, collaboration, and bibliographic signals. It prioritizes monitoring and is not a judgment of research quality.
Related topics: Plasma Applications and Diagnostics · Medical and Biological Ozone Research · Wound Healing and Treatments
Thai researcher and institutional participation
Lalita Jaingim · Kanlayanee Sittiwat · Kotchawan Nongyam · Konlawij Trongtrakul · Chiang Mai University · Maharaj Nakorn Chiang Mai Hospital
Data limitations
This page is a bibliographic record based on abstract-level information, not a full analysis or quality assessment. Verify the DOI and original article before citation.