Information from the abstract
Hypertrophic cardiomyopathy (HCM), the most common cardiac disease in cats, is associated with genetic variants, including MYBPC3, which encodes cardiac myosin-binding protein C (cMyBP-C), a key sarcomeric protein involved in myocardial contractility. Although circulating cMyBP-C has emerged as a biomarker of myocardial injury in humans, its clinical relevance in feline HCM remains unclear. This study characterized plasma cMyBP-C and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations across different stages of feline HCM, evaluated their diagnostic performance, and assessed their associations with echocardiographic parameters. A cross-sectional study included 65 cats: 25 healthy cats, 25 with subclinical HCM, and 15 with clinical HCM (chronic and treated). Plasma NT-proBNP was significantly higher in clinical HCM than in healthy cats (p = 0.0117), whereas plasma cMyBP-C was lower in clinical HCM than in subclinical HCM (p = 0.0462) and healthy cats (p = 0.001). At a cut-off of
Why this record is monitored
This record has an Impact Signal of 77/100 based on recency, source, collaboration, and bibliographic signals. It prioritizes monitoring and is not a judgment of research quality.
Related topics: Cardiovascular Conditions and Treatments · Cardiomyopathy and Myosin Studies · Cardiovascular Effects of Exercise
Thai researcher and institutional participation
Nutcha Tanakwang · Natcha Sakunasing · Sarawut Kumphune · Raktham Mektrirat · Kannika Na Lampang · Chavalit Boonyapakorn · Wanpitak Pongkan · Chiang Mai University
Data limitations
This page is a bibliographic record based on abstract-level information, not a full analysis or quality assessment. Verify the DOI and original article before citation.