Successful treatment of metformin-associated lactic acidosis without hemodialysis

Information from the abstract

Abstract Objectives Metformin-associated lactic acidosis (MALA) is a rare but potentially life-threatening condition. Hemodialysis is often recommended, but evidence of successful nondialytic management in children is limited. We report a girl with MALA successfully treated with supportive medical management without dialysis. Case presentation We report a girl with nondialyzed chronic kidney disease (CKD) and non–insulin-dependent diabetes mellitus (NIDDM), and dyslipidemia who developed MALA after 18 months of metformin, insulin, and sodium bicarbonate therapy. She presented with dyspnea, palpitations, and vomiting. She was lethargic, afebrile, tachypneic, tachycardic, hypertensive, and had Kussmaul breathing. Laboratory results showed blood glucose 55 mg/dL, potassium 6.7 mEq/L, arterial pH 7.038, pCO 2

Why this record is monitored

This record has an Impact Signal of 71/100 based on recency, source, collaboration, and bibliographic signals. It prioritizes monitoring and is not a judgment of research quality.

Related topics: Renal function and acid-base balance · Acute Kidney Injury Research · Diabetes Management and Research