Information from the abstract
SARS-CoV-2 infection is linked to hematologic abnormalities, but whether early hematopoietic compartments and their stromal niche are directly engaged remains unclear. We used in vitro exposure models to compare variant-associated responses of adult mesenchymal stromal cells (MSCs) and umbilical cord blood (UCB) CD34 ⁺ hematopoietic stem and progenitor cells (HSPCs). Adipose-derived (AD) and bone marrow-derived (BM) MSCs exposed to wild-type, Delta, or Omicron showed source- and variant-dependent nucleocapsid protein (NP) positivity, highest with Omicron in AD-MSCs; infectious virus in supernatants was undetectable. AD-MSCs expressed higher neuropilin-1 (NRP1) than BM-MSCs, and NRP1 knockdown reduced Omicron-associated NP signal, implicating an NRP1-linked entry process. SARS-CoV-2 exposure induced indoleamine-2,3-dioxygenase 1 (IDO1), most prominently in AD-MSCs. In UCB CD34 ⁺ HSPCs, Omicron increased NP positivity enriched in long-term HSCs, reduced primitive fraction frequencies, increased colony formation, and promoted early erythroid progenitor accumulation; heat-inactivated virus did not. NanoString profiling revealed host-response activation and altered cell-cycle/differentiation programs. These data indicate Omicron can engage stromal and early hematopoietic compartments and remodel stress-responsive hematopoiesis.
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Related topics: SARS-CoV-2 and COVID-19 Research · Mesenchymal stem cell research · COVID-19 Clinical Research Studies
Thai researcher and institutional participation
Kanit Bhukhai · Nopmullee Tanhuad · Pornprapa Srimorkun · Suwimon Manopwisedjaroen · Wittaya Panvongsa · Vimvara Vacharathit · Phongthon Kanjanasirirat · Umnuaychoke Thongsa-ad · Supasek Kongsomros · Chanya Srisaowakarn · Tulyapruek Tawonsawatruk · Patompon Wongtrakoongate · Nittaya Boonmuen · Suparerk Borwornpinyo · Usanarat Anurathapan · Arthit Chairoungdua · Nithi Asavapanumas · Suradej Hongeng · Arunee Thitithanyanont · Mahidol University · Ramathibodi Hospital · Ramathibodi Chakri Naruebodindra Hospital
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