A Prince of Songkla University team tested hypertonic sodium chloride against Staphylococcus aureus and Pasteurella canis, reporting antibacterial, antibiofilm and lower inflammatory-stimulation signals in vitro, plus a 77.5% bacterial-count reduction in a preliminary mouse oral-wound model.
Key findings
- Salt-tablet inhibition zones were 13.33 mm for S. aureus and 28.75 mm for P. canis, versus 23.10 and 31.43 mm for chlorhexidine. The 1% and 10% solutions maintained over 80% cell viability and reduced biofilm and NO signals; mouse bacterial counts fell from 8.9×10^2 to 2.0×10^2 CFU/mL.
Why this matters globally
If validated in companion animals, a low-cost, easily stored local approach could help settings with limited access to veterinary dental products. It must first be compared with standard care and assessed for tissue and commensal-microbiome effects.
Thai researcher contribution
Nine Prince of Songkla University authors span science, veterinary medicine and antimicrobial-biomaterial innovation, integrating materials, microbiology and animal-health expertise.
Limitations to consider
Most evidence is in vitro or from mice rather than diseased dogs or cats. A 30-minute exposure may not reflect use, and irritation, pain, ingestion, sodium burden, wound healing and long-term oral-microbiome effects remain unknown.
Verify the original sources
SciRead the original article↗DOI: 10.3390/sci8070168