The ASF/OA hydrogel reduced TNF-α secretion, increased Arg1 expression and enhanced vascularization in the CAM model without detectable irritation.
Key findings
- Reduced TNF-α and increased Arg1
- Enhanced vascularization in the CAM model
- Required no exogenous growth factor
Why this matters globally
The work proposes a material-driven wound-healing paradigm that reduces reliance on added growth factors or cells.
Thai researcher contribution
Researchers from Chulalongkorn University and Mahidol University contributed.
Limitations to consider
The evidence remains preclinical, relying on macrophage assays, HET-CAM and chick CAM models. These models cannot directly establish wound-healing efficacy in mammals or humans, and experimental concentrations may not reflect clinical use. In vivo wound models, longer-term biocompatibility studies and safety evaluation are required before clinical translation.