A pooled Thai cohort of 127 patients undergoing peroral endoscopic myotomy in 2014-2024 achieved 89.9% clinical success with improved symptom, relaxation-pressure, and timed-barium measures. Comparison with published Singaporean and Malaysian cohorts totaled 250 patients, but cross-study comparison cannot attribute outcome or reflux differences to treatment technique.
Key findings
- Clinical success was 89.9% in Thailand, 93.0% in Singapore, and 93.4% in Malaysia. Thai Eckardt scores, integrated relaxation pressure, and timed-barium parameters improved (p
Why this matters globally
The data inform adoption of advanced endoscopy in Southeast Asia and support standardized efficacy and reflux registries, but are not a head-to-head country comparison.
Thai researcher contribution
Thammasat University's digestive-disease center assembled more than a decade of Thai POEM experience and placed it within regional evidence.
Limitations to consider
The observational cohort lacks another-treatment comparator. Follow-up, reflux ascertainment, expertise, and case mix may differ by country; published cohorts limit harmonization and missing-data control. Eckardt ≤3 does not capture all quality of life, and detailed adverse events are absent from the abstract.