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Evidence of global relevance

Translational Evaluation of Interpretable Machine Learning for Cardiovascular Risk Prediction: Calibration Decomposition, Subgroup Audits, and Decision-Utility Analysis

An evaluation of 308,774 records compared cardiovascular-risk models. Histogram gradient boosting achieved PR-AUC 0.3177, AUROC 0.8407 and Brier score 0.0633, alongside subgroup calibration and decision-utility audits.

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Key findings

  • Histogram gradient boosting achieved PR-AUC 0.3177, AUROC 0.8407, Brier 0.0633 and ECE 0.0045. Discrimination was stable across subgroups, calibration varied by age and self-rated health, and net benefit was positive at thresholds 0.05–0.15.
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Why this matters globally

The study reinforces that clinical AI evaluation must go beyond discrimination to include calibration, subgroup equity and decision consequences at clinically relevant thresholds.

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Thai researcher contribution

Mahasarakham University researchers contributed a translational evaluation framework linking explainability, calibration decomposition and decision utility.

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Limitations to consider

This was secondary data, with population source and label collection not fully described in the abstract. External and prospective validation are absent, and subgroup calibration may shift with setting and prevalence.

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Verify the original sources

International Journal of Analysis and ApplicationsRead the original article

DOI: 10.28924/2291-8639-24-2026-202

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