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Evidence of global relevance

Prevalence and prognostic impact of unrecognized myocardial infarction detected by cardiac magnetic resonance in Thai patients with obesity

Among 1,053 Thai patients with BMI at least 25 kg/m2 who underwent cardiac magnetic resonance, 9.9% had scars consistent with previously unrecognized myocardial infarction. This group had more major cardiovascular events over a median 9.2 years, but most participants were selected for CMR because coronary disease was suspected, so this is not population prevalence among people with obesity.

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Key findings

  • UMI was found in 105 patients (9.9%). Over median 9.2-year follow-up, MACE rates were 2.58 versus 0.89 per 100 patient-years, with HR 2.86 (95% CI 1.68-4.88; p
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Why this matters globally

The study adds long-term Asian evidence on occult infarct scars and risk stratification among clinically referred patients, but does not support population screening.

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Thai researcher contribution

Siriraj cardiology researchers assembled a large Thai cohort with more than nine years of median follow-up, linking CMR findings to clinically meaningful cardiac outcomes.

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Limitations to consider

This is a single-center observational cohort; 78.3% underwent CMR for suspected coronary disease, creating referral bias and residual confounding. BMI ≥25 follows an Asian threshold. Scar detection does not establish timing or cause, and no randomized evidence shows that learning UMI status or changing treatment reduces events.

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Verify the original sources

PLoS ONERead the original article

DOI: 10.1371/journal.pone.0353109

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