After a three-minute educational video, 87% of 772 women showed good FXS understanding, 82% accepted carrier-screening in principle and 95% accepted prenatal investigation. Higher education was associated with knowledge and policy support.
Key findings
- Higher education predicted knowledge (aOR 1.66; 95% CI 1.23-2.23) and policy support (aOR 1.83; 1.35-2.48). Older age was modestly associated per year with lower knowledge, disclosure intent and agreement with continuing an affected pregnancy.
Why this matters globally
FXS is a leading inherited cause of intellectual disability, and this Asian evidence informs screening models that combine accessible education with diverse reproductive choices.
Thai researcher contribution
The Prince of Songkla, Songklanagarind, Sirindhorn and KMITL collaboration integrates paediatrics, genetics, obstetrics and data science for Thai policy evidence.
Limitations to consider
Without a pre-video measure, educational impact cannot be estimated. Immediate hypothetical acceptance at one clinic is vulnerable to selection and social-desirability bias and does not capture psychological or real-world decisions.