A narrative review of 32 studies proposes insulin resistance, low-grade inflammation and advanced glycation end products as pathways by which prediabetes may impair bone remodeling. Direct prospective orthognathic-surgery evidence remains insufficient for specific guidelines.
Key findings
- Emerging evidence links prediabetes to insulin resistance, inflammation and AGEs that may attenuate the post-surgical acceleratory phenomenon. Assays and sampling windows are highly heterogeneous, with a lack of prospective surgical trials.
Why this matters globally
Prediabetes is common and underdiagnosed. Considering bone healing broadens perioperative assessment beyond overt diabetes, but routine screening or intervention requires direct evidence.
Thai researcher contribution
Four Chiang Mai University dentistry researchers in oral-maxillofacial surgery and orthodontics synthesized this clinical question.
Limitations to consider
Despite a broad search, this is narrative and the abstract gives no protocol, quality appraisal or risk-of-bias process. Much evidence may be extrapolated from other populations or surgeries, prediabetes definitions vary and no pooled effect is provided.