Comparing isolated mouse endometrial epithelial cells on pregnancy days 1 and 4, researchers found 80 differentially expressed spots among approximately 674 and identified 52 proteins. Day 4 showed coordinated antioxidant and ER-stress-associated increases, with Gstm2 elevated at protein and transcript levels. This is a candidate pathway map, not proof that Gstm2 controls human implantation.
Key findings
- Approximately 674 spots were detected; 80 differed by at least twofold with p
Why this matters globally
Uterine receptivity limits reproductive success in humans and animals. The study suggests coordinated redox and protein-folding adaptation as part of the receptive window and supplies candidates for functional experiments.
Thai researcher contribution
Chiang Mai University, Naresuan University, and Silpakorn University collaborated with Taiwanese institutions. AgOmics-CMU and CMU's Functional Feed Innovation Center contributed omics and reproductive expertise. Publisher data confirm Naresuan University rather than the secondary database's hospital mapping.
Limitations to consider
This mouse study compared only two timepoints. Two-dimensional gels can miss low-abundance, membrane, and some isoform proteins. Associations do not establish function; only selected candidates were validated, with no perturbation or implantation outcome.