An integrative review proposes three author-developed frameworks—Multi-Barrier Phytogenic Defence, Resistance-Indexed Phytochemical Selection, and a Translational Readiness Score—to organise evidence on thymol, eugenol, cinnamaldehyde, citral, curcumin, and resveratrol against mycotoxigenic feed fungi. These are conceptual tools, not externally validated standards.
Key findings
- The review prioritises thymol, eugenol, cinnamaldehyde, citral, curcumin, and resveratrol based on multi-target coverage, ergosterol independence, efflux-pump evasion, biofilm penetration, GRAS status, and feed-matrix stability. The abstract does not report systematic search, selection, or quantitative weighting procedures.
Why this matters globally
Mycotoxigenic fungi affect animal health, productivity, and food chains globally. Multi-target strategies may reduce single-agent dependence and structure formulation design, but claims of geometrically lower resistance probability remain theoretical without long-term evolution experiments.
Thai researcher contribution
Maejo University's engineering and agro-industry faculty, International College, international innovation centre, and Phrae campus collaborated with Bhutan's livestock sector to build an applied feed-system framework.
Limitations to consider
This does not appear to be a systematic review: search strategy, risk-of-bias assessment, externally validated scoring, and independent-rater comparison are not reported. In-vitro studies vary in concentrations and matrices, and GRAS status does not guarantee safety across species and doses.