A retrospective cohort of 596 capecitabine-treated patients identified five predictors for grade 2–3 hand-foot syndrome. The internally validated model showed an optimism-adjusted C-statistic of 0.72 and good calibration.
Key findings
- 22.2% developed grade 2–3 HFS
- The final model used five predictors
- External validation is required before broader implementation
Why this matters globally
The model may support individualized toxicity surveillance and risk stratification for capecitabine treatment.
Thai researcher contribution
Researchers from Buddhasothorn Hospital, Chiang Mai University and Naresuan University developed the model.
Limitations to consider
The model was developed retrospectively at a single center and still requires external validation.