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Source-verified editorial analyses, ordered by latest publication date

1,037 analyses
public-health76IMPACT SIGNAL

GRB 241030A: A bright afterglow challenging forward shock emission

Context. Gamma-ray burst GRB 241030A ( z = 1.411) exhibited a particularly bright afterglow (similar to the ‘BOAT’, GRB 221009A), detected across gamma-ray, X-ray, UV, and optical bands. The extensive, multi-wavelength observations of this remarkable event provide a valuable opportunity to advance our understanding of GRB afterglow physics. Aims. We aim to constrain the physical properties of the jet, its microphysics, and the characteristics of the circumburst environment in the context of forward-shock emission. Methods. We compiled multi-wavelength observations spanning from a minute to a week after the prompt emission, processing the data through a unified photometry pipeline. Leveraging this comprehensive dataset, we analysed the observations both analytically and using Bayesian inference with two independent models. Our models assume that the afterglow emission arises from the strong forward shock of a laterally structured jet, with possible contributions from synchrotron self-Compton (SSC) scatterings. Results. We find that our models do reproduce the afterglow observations accurately, from the X-rays to the optical, favouring a jet propagating into a constant-density interstellar medium, with a viewing angle within the jet core. However, both analyses – with and without the inclusion of SSC scatterings – require parameter values that are extreme compared to expectations from standard theory. In particular, our results imply extremely energetic jets despite regular prompt energy, leading to a very inefficient prompt emission. Furthermore, the jets are particularly inefficient at accelerating particles, with low ϵ e and ϵ B , leading to significant SSC emission. Finally, our analyses indicate that the jets have large opening angles and propagate in high-density…

Thai researchers
multidisciplinary75IMPACT SIGNAL

Pioneering plant virology research for a healthier future: a summary of the 2025 American Society for Virology (ASV) Plant Virology Satellite Symposium

The American Society for Virology (ASV) 2025 Annual Meeting, held from 14 to 17 July at the Palais des congrès de Montréal and hosted by McGill University, featured a dedicated Plant Virology Satellite Symposium entitled "Pioneering Plant Virology Research for a Healthier Future." This symposium emphasized the inclusion of topics of significance to early-career scientists. The program highlighted advances across diverse areas of plant virology, including mechanisms of transgenerational virus transmission, the economic and biological impacts of grapevine viruses on viticulture, emerging plant virus vectors, and innovative applications of plant viruses as nanomaterials for cancer immunotherapy. Additionally, emerging research on small functional proteins encoded by plant viruses and plant defense mechanisms underscored the complexity of viral genomes and host interactions. The symposium showcased cutting-edge approaches and strategies aimed at addressing global challenges in plant health and food security.

Thai researchers
clinical-medicine75IMPACT SIGNAL

Global disparities in hearing care services and infrastructure: findings from a 47-country international provider survey

OBJECTIVE: Access to audiological services and support for individuals with hearing loss varies widely across low- and middle- income countries (LMICs) and high-income countries (HICs). This study examines disparities in the availability of audiological services across World Bank income groups. DESIGN: An international cross-sectional survey was developed and distributed by the Global Otolaryngology Head and Neck Surgery Initiative. The survey evaluated the availability of audiology and support services across countries. Multiple responses from one country were combined into one entry. Statistical significance between groups was assessed using chi-squared tests.Study Sample: A total of 135 responses were received from 47 countries (30 LMICs and 17 HICs). RESULTS: Significant disparities were identified across most service categories. HICs reported greater availability of newborn hearing screening, diagnostic tests, paediatric and adult hearing assessments, vestibular services, and hearing technologies compared to LMICs. Advanced diagnostic tools and hearing devices such as cochlear implants were significantly more accessible in HICs. CONCLUSIONS: Substantial differences were observed in audiological and rehabilitative services across HICs and LMICs. Efforts to bridge significant gaps are essential for achieving equitable hearing health care worldwide.

Thai researchers
clinical-medicine75IMPACT SIGNAL

Stapokibart provides significant improvements in signs and symptoms of atopic dermatitis irrespective of prior systemic treatment: a post-hoc analysis of a phase 3 trial

Objectives This post-hoc analysis of CM310AD005 conductedaimed to analyze the efficacy and safety of stapokibart in adults with moderate-to-severe atopic dermatitis (AD) with and without prior systemic treatment.Methods In CM310AD005, eligible patients were randomized 1:1 to receive stapokibart 600 (loading dose)-300 mg and placebo Q2W for 16 weeks; all patients subsequently received stapokibart 300 mg Q2W for 36 weeks.Results At week 16, in systemic treatment-naïve patients, stapokibart led to significantly higher response rates than placebo for ≥75% improvement from baseline in the Eczema Area and Severity Index score (EASI-75, 70.3% vs. 29.1%), EASI-90 (38.1% vs. 13.3%), Investigator’s Global Assessment score of 0 or 1 (45.2% vs. 19.4%), and ≥4-point reduction in weekly average of daily Peak Pruritus Numerical Rating Scale score (34.8% vs. 13.9%) (all p < 0.0001). Among patients with prior systemic treatment, these response rates were also significantly higher in the stapokibart group, reaching 61.5% vs. 19.3%, 35.4% vs. 7.2%, 42.7% vs. 9.6%, and 37.5% vs. 7.2% (all p < 0.0001), respectively. All patients showed further improvements through week 52. The most common treatment-emergent adverse events were infections and infestations, occurring in 61.6% and 70.5% of patients with and without prior systemic treatment.Conclusions Stapokibart demonstrated significant clinical efficacy and manageable safety in AD patients irrespective of prior systemic treatment.

Thai researchers
clinical-medicine75IMPACT SIGNAL

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Cytochrome P450 2D6 (CYP2D6)-mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor-positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype-phenotype correlation. To address these gaps, long-read Oxford Nanopore sequencing was applied to resolve CYP2D6 structural complexity and evaluate its impact on endoxifen metabolism. The study cohort included 492 Thai breast cancer patients, with multivariable analysis performed on 361 individuals receiving standard-dose tamoxifen to determine the association between CYP2D6 activity scores and plasma endoxifen concentrations. Long-read sequencing identified 82 distinct diplotypes and successfully resolved complex structural variations, including the prevalent CYP2D6*36 + *10 non-identical duplication. Overall, 46.55% of patients were classified as having decreased enzyme function, primarily intermediate metabolizers (45.53%). CYP2D6 activity score emerged as the strongest determinant of endoxifen exposure (P < 0.001). Decreased-function genotypes were significantly associated with lower endoxifen levels (using an exploratory benchmark of ≤5.97 ng/mL), independent of parent drug concentration. These findings demonstrate that long-read sequencing enables the precise resolution of CYP2D6 structural complexity. By accurately capturing rare and complex CYP2D6 alleles, the results indicate that standard genotyping may misclassify certain patients, potentially placing a large portion of the studied population at an unrecognized risk of low tamoxifen exposure.

Thai researchers
clinical-medicine75IMPACT SIGNAL

Membranous remodeling of basal infoldings in attenuated epithelial cells of dilated renal tubules under unilateral ureteral obstruction (UUO) in adult mouse kidney.

Under unilateral ureteral obstruction (UUO) in mouse kidneys, comparing proximal and distal tubules and collecting ducts, the distal tubules exhibited the most pronounced dilation and epithelial attenuation. Basal infoldings, typically well-developed in normal distal tubule cells, were infrequently present. Instead, the cell base was predominantly covered by flat-contoured plasma membranes interspersed with clusters of palisade-aligned thin cytoplasmic processes. These processes resembled the mitochondria-free terminal portions of cytoplasmic processes normally enclosed by basal infolding membranes in normal distal tubule cells. Some process clusters were enclosed by internal extensions of adjacent flat-contoured membranes, forming process-containing membranous sacs partially open to the basal interstitial space. Similar membranous bodies were observed deep within the cells, with some opening to intercellular spaces through fusion with lateral cell membranes. These membrane modifications likely represent the morphological sequence of membrane dynamics, providing additional membranes to compensate for the increased basal surface area in dilated tubules. Similarly, the collecting ducts dilated with attenuated epithelia and the basal surfaces were covered by flat-contoured plasma membranes with sparse clusters of palisade-aligned processes, suggesting basal infoldings, which also serve as a membrane supply to basolateral surfaces in these cells. However, membranous sacs containing thin processes were less frequent in collecting duct cells, indicating a less extensive membrane remodeling process compared with distal tubule cells. On the other hand, the proximal tubules exhibited the lowest luminal dilation and epithelial attenuation, and the replacement of the diminished…

Thai researchers
multidisciplinary75IMPACT SIGNAL

Constitutive DUSP2 expression enhances lymphoid cell proliferation by activating CDK1 and promotes lymphomagenesis

DUSP2 is known as a nuclear dual-specificity phosphatase, highly restricted to immune cells. Its expression is induced by antigenic and mitogenic stimuli and has been implicated in immune cell differentiation and functions. However, its role in immune cell mitotic proliferation and hematologic malignancies has not been rigorously examined. Here, we show DUSP2 is highly expressed in human B-cell, T cell, and other hematologic malignancies. Ablating DUSP2 expression in lymphoma cell lines decreases growth and viability. In mice, transgenic Dusp2 expression promotes B-cell and T cell proliferation, and malignant transformation. Mechanistically, DUSP2 promotes cell cycle progression by activating CDK1 through dephosphorylation at inhibitory Tyr15 and Thr14, which is mediated not by its own phosphatase activity, but instead by a structural motif that recruits CDC25 phosphatases. This work reveals an unexpected oncogenic role for DUSP2 in lymphoid malignancies and the function of a structural motif, which represents an appealing target site for therapeutic intervention.

Thai researchers
energy-materials75IMPACT SIGNAL

Influence of Alloy and Alloy Composition on Dendrite Formation and Electrochemical Performance in Aluminum Metal Batteries

Interfacial instability and sluggish kinetics of high-purity aluminum (Al) anodes remain major bottlenecks for rechargeable nonaqueous aluminum-ion batteries (AIBs) to achieve high electrochemical performance. This study systematically evaluates the effects of alloying compositions on dendrite formation in commercial AA1235, AA3003, and AA8006 Al alloys as scalable, high-performance and low-cost anodes in chloroaluminate-based electrolyte AIBs. Comprehensive results demonstrate that the commercial Al alloys achieve superior cycling stability over pure Al metal benefited by leveraging a balanced intermetallic distribution that promotes uniform Al plating and suppresses vertical dendrite propagation. In contrast, high-purity Al exhibits limited long-life cycles due to its inhomogeneous native oxides. Our findings reveal that tailored commercial alloys can outperform their high-purity materials, offering a strategic pathway for durable and cost-effective energy storage based on multivalent metal-ion chemistries.

Thai researchers
clinical-medicine75IMPACT SIGNAL

Adolescent sexual and reproductive health assessment in clinical practice in India: a qualitative study triangulating clinician practices and young adults’ experiences

OBJECTIVES: To characterise current practices in adolescent sexual and reproductive health (SRH) assessment during routine clinical encounters in a tertiary care setting and to triangulate these findings with young adults' experiences of adolescent healthcare, identifying gaps between recommended assessment approaches and real-world clinical practice. DESIGN: Qualitative study using semistructured in-depth interviews (IDIs) and group discussions with clinicians, followed by a sequential triangulation phase involving IDIs with young adults. Data were analysed using Braun and Clarke's reflexive thematic analysis. SETTING: A tertiary care hospital in South Karnataka, India. PARTICIPANTS: 33 clinicians across six departments participated in four IDIs and five group discussions (focus-group or small-group discussions). 10 undergraduate young adults were recruited for IDIs in the triangulation phase. Sampling was guided by the information power principle. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Current patterns and practices of SRH assessment, perceived barriers and challenges and concordance between clinician-reported practices and young adults' experiences of care. RESULTS: Three domains emerged: current assessment practices, contextual challenges and improvement strategies. SRH assessment was largely symptom-driven and reactive rather than routinely integrated into consultations. Clinicians described practices shaped by sociocultural stigma, parental presence, privacy limitations and medicolegal uncertainty. In response, many relied on informal strategies such as rapport-building, indirect questioning or referral pathways. Triangulation with young adults' experiences confirmed the reactive nature of SRH enquiry, but revealed critical mismatches: young adults…

Thai researchers
multidisciplinary74IMPACT SIGNAL

Correction: Enhancing Geomorphological Mapping in Northern Thailand Using Convolutional Neural Networks

ระเบียนนี้เป็นประกาศแก้ไขของบทความเดิมเรื่องการใช้โครงข่ายประสาทแบบคอนโวลูชันทำแผนที่ธรณีสัณฐานในภาคเหนือของไทย ไม่ใช่งานวิจัยฉบับใหม่ และแหล่งข้อมูลที่ระบบเข้าถึงไม่มีข้อความอธิบายว่ามีการแก้ไขส่วนใด จึงไม่ควรนับเป็นหลักฐานหรือผลงานใหม่แยกจากบทความต้นฉบับ ผู้อ่านควรเปิด DOI เพื่อตรวจรายการแก้ไขและอ่านควบคู่กับฉบับเดิม

Thai researchers
multidisciplinary74IMPACT SIGNAL

A biosecurity baseline for transboundary management of marine biological invasions in the ROPME Sea Area

Marine and brackish-water ecosystems are increasingly degraded by cumulative human pressures, with biological invasions representing a major driver of biodiversity loss, ecosystem disruption, and socio-economic impacts. Effective management requires regionally harmonised and scientifically robust baselines capable of supporting coordinated transboundary decision-making. Here we present the first consolidated marine biosecurity baseline for the Regional Organization for the Protection of the Marine Environment (ROPME) Sea Area, a transboundary region characterised by extreme environmental conditions and increasing biosecurity pressure. A total of 192 species (123 extant and 69 horizon), including birds, fishes, tunicates, invertebrates, plants, and chromists, were systematically reviewed, taxonomically validated, and cross-checked against major databases and Member State inputs. Re-evaluation of a previous regional screening resulted in 24 species (≈18%) requiring status correction or exclusion. The resulting consolidated inventory comprised 130 validated retained species supplemented by 62 additional taxa. Extant species were classified according to biogeographic origin and impact status, whereas horizon species were evaluated based on introduction pathways, environmental suitability, and projected climate trends. Risk screening under current and projected climate conditions identified 39 extant species as very high risk, providing an operational basis for progression to full risk assessment and coordinated regional biosecurity management.

Thai researchers
clinical-medicine74IMPACT SIGNAL

One Health surveillance of Lassa fever in Oyo State, Nigeri

Introduction: Lassa fever (LF) is a severe viral haemorrhagic disease caused by Lassa virus (LASV) and remains endemic in Nigeria, where it is associated with recurrent outbreaks, substantial morbidity, and high mortality. The persistence of LF is driven by weak surveillance systems, limited diagnostic capacity, poor health-seeking behaviour, and complex interactions at the human–rodent–environment interface. In endemic settings, these factors contribute to under-detection of cases and sustained transmission. This study adopted a One Health-informed approach to assess the sero-molecular prevalence of LASV in humans, evaluate viral detection in rodents recovered following bait-based deratization activities and examine the influence of meteorological factors on LF occurrence in Oyo State, Nigeria. Methods: Between January 2022 and April 2023, a cross-sectional study was conducted across selected high-risk LGAs in Oyo State. Blood samples (n = 289) were collected from febrile patients and screened for LASV using RT-qPCR and IgM/IgG ELISA. Rodents (n=30) were recovered in Iwajowa LGA, they were morphologically identified and tested for LASV using RT-qPCR. Meteorological data were obtained from the Nigerian Meteorological Agency to evaluate associations between climatic variables and LF occurrence. Data were analysed using descriptive statistics and bivariate correlation analysis. Results: The overall LASV seroprevalence was 11.1% (32/289), comprising IgM positivity in 9.7%, IgG positivity in 4.8%, and dual IgM/IgG positivity in 3.5% of participants; three samples (1.0%) were confirmed positive by RT-qPCR. All recovered rodents tested negative for LASV RNA. Notably, no Mastomys species were recovered, while Rattus rattus, Mus musculus, and Cricetomys gambianus predominated…

Thai researchers
BIBLIOGRAPHIC RESEARCH WATCHLIST

Bibliographic research records

Thailand-affiliated bibliographic records. These are not full analyses; they are ordered by Impact Signal and should be verified against the original source.

3,510records
3,510 records
73IMPACT SIGNAL
Clinical Medicine

Dual bispecific protein engager–armed T cells targeting BCMA and B7-H3 overcome antigen heterogeneity in multiple myeloma

Biomedicine & Pharmacotherapy

Thailand-affiliated authors
Thanida Chanpong · Nunghathai Sawasdee · Kamonlapat Supimon · Thanich Sangsuwannukul · Thaweesak Chieochansin · Pa‐thai Yenchitsomanus · Mutita Junking
Institutions
Siriraj Hospital
73IMPACT SIGNAL
Clinical Medicine

Evaluation of acoustic pulse and cold laser therapies for the treatment of dairy cows with subclinical mastitis under organic management conditions

Frontiers in Veterinary Science

Thailand-affiliated authors
Guy Jodarski
Institutions
Ministry of Agriculture and Cooperatives
73IMPACT SIGNAL
Multidisciplinary

Just how far off target are we? Measuring unmet pre-exposure prophylaxis need among men who have sex with men and transgender women in Asia-Pacific

Sexual Health

Thailand-affiliated authors
Nittaya Phanuphak
Institutions
Bangkok University
73IMPACT SIGNAL
Digital Health

An analogical argumentation framework for argumentative local explainers

Argument & Computation

Thailand-affiliated authors
Nguyen Duy Hung · Thanaruk Theeramunkong
Institutions
Thammasat University · The Royal College Of Anesthesiologists Of Thailand
73IMPACT SIGNAL
Clinical Medicine

Alpha-Mangostin in Acute Kidney Injury: Molecular Mechanisms, Regulated Cell Death, and Translational Opportunities

Antioxidants

Thailand-affiliated authors
Atthaphong Phongphithakchai · Nawanwat C. Pattaranggoon · Kraiyasak Wongna · Ratana Netphakdee · Aman Tedasen · Chutima Jansakun · Wiyada Kwanhian Klangbud · Jongkonnee Thanasai · Moragot Chatatikun
Institutions
Prince of Songkla University · Walailak University · Nakhon Phanom University · Mahasarakham University
73IMPACT SIGNAL
Global Public Health

Biotechnological Advances of Lactic Acid Bacteria in Maghrebian Countries: An Updated Review

Biotechnology and Applied Biochemistry

Thailand-affiliated authors
Pankaj Koirala · Nilesh Prakash Nirmal
Institutions
Mahidol University
73IMPACT SIGNAL
Energy and Materials

Fe-doped BiVO4/g-C3N4 heterojunction for efficient tetracycline degradation under low-intensity UV irradiation

Scientific Reports

Thailand-affiliated authors
Supakorn Boonyuen
Institutions
Thammasat University
73IMPACT SIGNAL
Clinical Medicine

Parametric study of electrohydrodynamic flow and heat transfer in a wind tunnel using thermochromic liquid crystals and smoke tracing

Scientific Reports

Thailand-affiliated authors
K. Wongcharee · D. Chutrakul · V. Chuwattanakul · S. Eiamsa-ard
Institutions
Mahanakorn University of Technology · King Mongkut's Institute of Technology Ladkrabang
73IMPACT SIGNAL
Clinical Medicine

Evidence- and opinion-based consensus from Delphi round 1 of the Asian aplastic anemia recommendation development

International Journal of Hematology

Thailand-affiliated authors
Surapol Issaragrisil
Institutions
Siriraj Hospital · Mahidol University
73IMPACT SIGNAL
Clinical Medicine

Severe fever with thrombocytopenia syndrome complicated by invasive pulmonary aspergillosis and septic shock: a case report highlighting the role of mNGS

Frontiers in Medicine

Thailand-affiliated authors
Mingzhi Fan
Institutions
Police General Hospital
73IMPACT SIGNAL
Environmental Engineering

Biphasic Oxidative Carboxylation of Aliphatic Olefins With H 2 O 2 to Produce Useful Cyclic Carbonates

Advanced Synthesis & Catalysis

Thailand-affiliated authors
Surajchaya Kheawmuan · Suthida Kaewsai · Wuttichai Natongchai · Pipat Na Ranong · Silvano Del Gobbo · Valerio D’Elia
Institutions
Vidyasirimedhi Institute of Science and Technology
73IMPACT SIGNAL
Clinical Medicine

Multifactorial influences on lung function in farmers: personal, occupational, and health-related factors

Journal of Environmental Science and Health Part B

Thailand-affiliated authors
Patchareeya Amput · Ajchamon Thammachai · Saisunee Konsanit · Patcharin Phrompao · Sirima Wongphon
Institutions
University of Phayao
73IMPACT SIGNAL
Environmental Engineering

A novel multi-criteria group decision-making technique in traffic flow and safety assessment using interval-valued complex spherical fuzzy soft set

Scientific Reports

Thailand-affiliated authors
Saalam Ali · Hamza Naveed
Institutions
King Mongkut's University of Technology Thonburi
73IMPACT SIGNAL
Clinical Medicine

Exploring the Reasons Behind the Low Purchase Rate of CPAP Machines Among Adult Patients With Obstructive Sleep Apnea Through Qualitative Research

Social Marketing Quarterly

Thailand-affiliated authors
Bundit Sawunyavisuth · Darunee Jongudomkarn · Kittisak Sawanyawisuth
Institutions
Khon Kaen University
73IMPACT SIGNAL
Environmental Engineering

Preharvest temperature treatments influence physiological traits, secondary metabolites, and volatile compounds in holy basil under controlled environment conditions

Scientific Reports

Thailand-affiliated authors
P. Boonkorkaew · Niafnan Hayi-asan · Akira Thongtip · Wannida Sae-Tang · Atikorn Panya · Natthaporn Phonsatta · Sujichon Thangvichien · Prapussorn Yingcharoen · Panita Chutimanukul
Institutions
Kasetsart University · National Science and Technology Development Agency · National Center for Genetic Engineering and Biotechnology
73IMPACT SIGNAL
Environmental Engineering

Nationwide and regional evidence on PM2.5-mortality in a tropical climate: Risks persist below standard and under climate extremes

Ecotoxicology and Environmental Safety

Thailand-affiliated authors
Phichet Khunthong · Panuwat Vittayapraparat · Sitthichok Puangthongthub
Institutions
Chulalongkorn University
73IMPACT SIGNAL
Clinical Medicine

Two Mechanisms One Molecule: Developing a ‘Truly’ Bifunctional Degrader Targeting Rpn13 and CRBN

Journal of the American Chemical Society

Thailand-affiliated authors
Cody A. Loy · Shawn E. Vinogradsky · Darci J. Trader
Institutions
Mahidol University
73IMPACT SIGNAL
Multidisciplinary

CD163+ perivascular macrophages in schizophrenia: a research framework for testing macrophage-related mechanisms

Frontiers in Psychiatry

Thailand-affiliated authors
Chavit Tunvirachaisakul · Michael Maes
Institutions
Chulalongkorn University
EDITORIAL STANDARD

How we select research

We use OpenAlex, Crossref, PubMed, DOI records, and publisher pages, then verify Thai researcher participation before publication.

  1. 01Discover new researchFocus on the latest 90 days and verifiable Thai affiliations
  2. 02Assess signalsReview recency, quality, collaboration, and societal relevance
  3. 03Read with careReport findings with limitations and avoid claims beyond the evidence
  4. 04Open original sourcesEvery item includes a DOI, review date, and verification link