Genomic surveillance of carbapenem-resistant Acinetobacter baumannii from bloodstream infections in Thailand reveals widespread dissemination of blaNDM–harboring mobile genetic elements
Whole-genome surveillance of 41 carbapenem-resistant A. baumannii bloodstream isolates collected across Thailand in 2020-2024 found widespread international clone II (ST2). Resistance was dominated by blaOXA-23 with intrinsic blaOXA-66 and a penicillin-binding-protein mutation. A conserved blaNDM-5 mobile element appeared across ST2 sublineages and regions, consistent with horizontal spread followed by clonal expansion; blaNDM-1 was less frequent and linked to Tn125 in ST2 and ST16.