Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats
A rat experiment tested lactation as a developmental reprogramming window by giving dams, whose offspring had or had not experienced fetal undernutrition, cocoa-shell extract at 250 mg/kg/day. Although adult undernourished offspring had lower blood pressure, several groups developed adverse cardiac function, vascular relaxation and arterial-wall changes.
Thai researchersMetee Iampanichakul