Distinct genomic landscape of colorectal signet ring cell carcinoma reveals frequent KMT2 family alterations and SMAD4 inactivation
Targeted profiling of 517 cancer genes in 39 colorectal signet-ring cell carcinomas found KMT2C and SMAD4 alterations in 49% each, while canonical drivers such as APC and KRAS appeared less often than typically reported in conventional adenocarcinoma. This points to epigenetic and TGF-β hypotheses but does not yet guide treatment.