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EDITORIAL DEEP DIVES

In-depth research analyses

Source-verified editorial analyses, ordered by latest publication date

972 analyses
Clinical Medicine89IMPACT SIGNAL
Global potential

Visual Impairment Was Associated With Nearly Threefold Higher Odds of Frailty Progression in Thai Older Adults

This retrospective cohort from the Siriraj Primary Care Unit followed 400 community-dwelling older adults, with a median age of 70 years and 76% women. Visual impairment was defined as visual acuity worse than 6/12 in the better-seeing eye, and frailty was assessed with the Thai FRAIL scale. Ordinal logistic regression found an association with transition to a worse frailty state: adjusted odds ratio 2.98 (95% CI 1.97–4.52; p

Thai researchersChutimon Thongkhao-On · Harisd Phannarus · Aliyah Famitynond · Pornchita Thanakorn · Thitiya Jenjirojpipat · Thiwarut Kraikaitsakul · Varalak Srinonprasert
Fundamental Cancer Biology89IMPACT SIGNAL
Global potential

NECTIN2 Depletion Cut Migration and Invasion by About Half, but Only in One Triple-Negative Breast Cancer Cell Line

This study asked whether the cell-surface adhesion molecule NECTIN2 contributes to motility and invasion in triple-negative breast cancer. The team combined public-dataset analyses with stable NECTIN2 depletion in MDA-MB-231 and MDA-MB-468 cells. The major phenotype was confined to MDA-MB-231: migration and invasion fell by about 50%, accompanied by lower LIMK1 and cytoskeletal changes, while LIMK1 re-expression partially restored migration. The findings support a context-dependent mechanism, not a clinically validated drug target or proof that NECTIN2 inhibition prevents metastasis in patients.

Thai researchersPhatchanat Klaihmon · Pattaratorn Muangtate · Sudarat Thongphayong · Puretat Saetan · Supasorn Chanthateyanonth · Chanitra Thuwajit · Surapol Issargrisil · Phatchariya Phannasil
Antimicrobial Stewardship92IMPACT SIGNAL
Stepped-Wedge Cluster Randomized Trial

A Smartphone Antimicrobial Prescribing App Did Not Outperform Paper Guidelines Across Six Lao Hospitals

Across a stepped-wedge cluster randomized trial in six Lao hospitals, a smartphone version of national antimicrobial prescribing guidelines plus one stewardship training session did not significantly improve adherence over paper versions after adjustment for time, clustering, and confounders. Inpatient adherence was 25.6% versus 17.0% before adjustment, but the adjusted odds ratio was 1.26 (95% CI 0.8–1.9; p=0.276); outpatient results were also null. The finding argues for sustained, multifaceted stewardship rather than guideline access alone.

Thai researchersSue J. Lee · Mavuto Mukaka · Nicholas P. J. Day · Paul N. Newton
Digital Health and Nutrition92IMPACT SIGNAL
Model-development and benchmark evidence

Two-Stage Model Classifies 46 Produce and Vegetable-Dish Categories at 92.43% Top-1 Accuracy, but Lacks On-Device Validation

The study developed a two-stage ThaiSook pipeline: a binary model first rejects non-produce images, after which a multiclass model identifies 43 fruit and vegetable types and three vegetable-heavy dishes. The 40,595-image dataset contained 11,210 labelled and 29,385 unlabelled user images. With label smoothing and temperature scaling, the pipeline reached 92.43% top-1, 94.56% top-3, and 94.91% top-5 accuracy; Noisy Student raised top-1 accuracy to 92.59%. However, results rely on one train–test split, without real on-device testing or evidence that classification improves dietary measurement or health outcomes.

Thai researchersDecho Surangsrirat · Panyawut Sri-iesaranusorn · Polathep Vichitkunakorn
Health Policy and Cancer-Medicine Access88IMPACT SIGNAL
Global potential

Lower-Income Asia-Pacific Settings Reported Full Out-of-Pocket Cost for 95.2% of High-Benefit Medicine–Country Pairs

This predefined regional analysis of ESMO's 2023 global survey covered 20 Asia-Pacific countries and compared WHO essential cancer medicines with high-benefit medicines under ESMO-MCBS. The findings show that marketing availability does not equal reliable access: reimbursement and patient out-of-pocket burden remain major bottlenecks. Access was generally stronger in high-income economies, while middle- and lower-income groups faced large gaps, particularly for high-benefit medicines. The evidence is expert-reported and cross-sectional, and income-group aggregates must not be presented as Thailand-specific estimates.

Thai researchersNaiyarat Prasongsook · Lucksamon Thamlikitkul
Geospatial Agriculture and Environment89IMPACT SIGNAL
Regional model-validation evidence

GEDI–Sentinel Model Maps Northeast Thai Rubber at 82.63% Accuracy but Struggles With Young Plantations

This study mapped 2024 rubber distribution and age structure across Northeast Thailand using Random Forest in Google Earth Engine, combining Sentinel-1, Sentinel-2, vegetation indices, and a GEDI-trained canopy-height model. Three-class rubber mapping reached 82.63% overall accuracy and about 0.84 F1; three-group age classification reached 83.39%. Plantations older than seven years dominated and were classified more reliably than young stands. The output is a regional monitoring baseline, not an error-free parcel-level decision map.

Thai researchersSavittri Ratanopad Suwanlee · Muhammad Hanif · Surasak Keawsomsee · Kemin Kasa · Narissara Nuthammachot · Sarawut Ninsawat · Jantima Polpinij · Jaturong Som-Ard
Medical Education and Serious-Illness Care89IMPACT SIGNAL
Longitudinal training evidence

Advance-Care-Planning Training Raised Residents’ Knowledge From 7.74 to 8.65, but Had No Control Group

This mixed-methods evaluation tested an Advance Care Planning programme combining role-play, personal-value reflection, and two Circle of Learning sessions with an entire cohort of 50 first-year internal-medicine residents. Longitudinal analysis used 34 complete cases through 15 months, and 10 residents were interviewed. Knowledge rose from 7.74 to 8.65 out of 9, alongside several attitude and confidence improvements. Interviewees said role-play bridged theory and practice but identified a need for ongoing workplace support. The evidence concerns learner readiness, not observed conversation quality or patient outcomes.

Thai researchersThagoon Kanjanopas · Smuch Siramongkholkarn · Wanna Jarusomboon · Ekkapop Sittiwantana · Arisa Phochaisarn · Saipin Hathirat · Saran Thanapluetiwong
Public Health and Migrant Health92IMPACT SIGNAL
Evidence of global relevance

Migrant TB Patients Chose Months-Long Sanatorium Care to Pursue Cure Amid Cost, Transport, and Documentation Barriers

This multi-perspective qualitative study at the SMRU tuberculosis sanatorium in Mae Ramat, Tak Province, examined why migrants choose long residential treatment. It included 37 unique patients—33 who chose the sanatorium and four who chose community DOTS—plus five health workers. Three themes organized the findings: desire for cure, barriers to diagnosis and treatment, and community and organizational support.

Thai researchersJindaporn Wirachonphaophong · Hai Ti Ti · Nay Kaw Htoo · Kanjana Winyoorat · Cha Ba · San Soe · Suphak Nosten · Htet Ko Ko Aung · Sein Sein Thi · Francois Nosten
Public Health and Health Systems92IMPACT SIGNAL
Qualitative evidence for service design

Patients in South Ethiopia Know How to Manage Diabetes, but Drug Shortages and Costs Undercut Self-Care

This qualitative study examined diabetes self-care in three South Ethiopian hospital clinics. Its 21 participants comprised 12 adults with type 2 diabetes and nine healthcare providers. Patients described medication, diet, physical activity, foot care, and glucose monitoring as daily work negotiated against financial pressure, drug shortages, beliefs, food costs, limited support, and health-system constraints. Patients tended to foreground structural barriers, whereas providers placed more emphasis on knowledge and forgetting advice. Continued counselling, reliable medicines, and peer support emerged as priorities, but these are interview-derived design directions rather than tested interventions.

Thai researchersTemesgen Anjulo Ageru · Cua Ngoc Le · Apichai Wattanapisit · Charuai Suwanbamrung
International Journal of Qualitative Studies on Health and Well-beingRead analysis →
Forest Policy and Bioeconomy92IMPACT SIGNAL
Evidence of global relevance

Perspectives on the forest bioeconomy: insights of stakeholders from cases in Central Europe and the Mekong region

This comparative study examines how 336 purposively recruited respondents in Czechia, Slovakia, Thailand, Laos and Vietnam understand and assess the forest bioeconomy. Respondents generally reported stronger familiarity with sustainable forest management and the circular economy than with the bioeconomy itself. Perceptions also varied across country cases, particularly within the Mekong region. A binary logistic regression identified associations between high perceived implementation and country, age, education, understanding of policy aims, support for implementation and positive assessments of forest-industry implementation. These findings describe perceptions within the recruited sample rather than national populations, and the reported associations should not be interpreted as causal effects.

Thai researchersNopparat Kaakkurivaara · Alice Sharp · Prasit Wangpakapattanawong
One Health and Zoonotic-Disease Prevention92IMPACT SIGNAL
Formative evidence for One Health intervention design

Zoonotic Risk in Rural Nan Is Not Just Behavioural: Water Scarcity, Forest Change, and Food Systems Connect Five Interfaces

Researchers examined everyday practices and conditions that could enable cross-species transmission in four rural villages in Nan Province, organising findings into five interfaces: human–animal, human–environment, human-human, animal–animal, and animal–environment. The picture is not simply one of deficient knowledge. Animal contact, butchering and food preparation, water scarcity and contamination, waste, forest change, intensified agriculture, mixed-species proximity, and multilingual communication operate as a system. Community leaders and village health volunteers were viewed as trusted messengers. The study therefore recommends education that combines knowledge, skills, practical tools, and recognition of structural limits, but it neither completed nor evaluated the final intervention.

Thai researchersMonchai Phongsiri · Simaphon Tomklang · Theerayuth Labooth · Thanapat Chaibut · Pongsakon Jaruton · Kotthamon Chanprathad · Sarutaya Suphawatthanaphan · Hans Overgaard · Patcharin Lapanun
Circular Bioeconomy and Seafood Technology92IMPACT SIGNAL
Comprehensive narrative-review evidence

Crustacean By-Products Hold High-Value Compounds, but ‘Green’ Extraction Still Lacks LCA and Industrial Proof

This review compares conventional acid–alkali and solvent extraction with supercritical fluids, enzymatic hydrolysis, pulsed electric fields, ultrasound, cold plasma, microwave, high-pressure processing, and deep eutectic solvents for recovering bioactives from crustacean by-products. No technology is universally optimal: conventional methods retain advantages in simplicity and maturity, while emerging methods may reduce chemicals or better preserve product quality but face equipment, cost, energy, reproducibility, and pilot-scale constraints. The paper is therefore a map of options and evidence gaps, not proof that one technology is the ‘most sustainable.’

Thai researchersAkanksha R. Gautam · Soottawat Benjakul · Rattikarn Boonchoosri · Nilesh Nirmal · Avtar Singh
BIBLIOGRAPHIC RESEARCH WATCHLIST

Bibliographic research records

Thailand-affiliated bibliographic records. These are not full analyses; they are ordered by Impact Signal and should be verified against the original source.

1,808records
1,808 records
75IMPACT SIGNAL
Clinical Medicine

Single-cell transcriptomic analysis of cutaneous squamous cell carcinoma identifies an NR1H3-associated angiogenic macrophage state

Frontiers in Immunology

Thailand-affiliated authors
Yong He · Ting Tian · Liming Li · Leqi Qian · Tian Tian · Xiaoke Wang · Yuancheng Li · Mingjun Jiang
Institutions
Institute of Dermatology
75IMPACT SIGNAL
Clinical Medicine

Hybrid artificial intelligence framework for patient emotion recognition in dentistry

Frontiers in Oral Health

Thailand-affiliated authors
Kanoksak Wattanachote · Taechinee Ratanawimon · Phawit Phanchantraurai · Wanlida Suphasri-itsara · Panupat Phumpatrakom · Samroeng Inglam · Siriwan Suebnukarn
Institutions
Mahidol University · Thammasat University
75IMPACT SIGNAL
Clinical Medicine

Dual bispecific protein engagers targeting mesothelin and NECTIN2 deliver CD3/CD28 signals to activate cytotoxic T cells against colorectal cancer patient-derived organoids

Scientific Reports

Thailand-affiliated authors
Suyanee Thongchot · Kamonlapat Supimon · Nattaporn Phanthaphol · Pattara Kanoksing · Titaporn Mitchasin · Woramin Riansuwan · Siriluck Prapasrivorakul · Pornraksa Ovartchaiyapong · Aitsariya Mongkhonsupphawan · Surat Phumphuang · Mutita Junking · Pa-thai Yenchitsomanus · Peti Thuwajit · Chanitra Thuwajit
Institutions
Siriraj Hospital · Mahidol University · Naresuan University
75IMPACT SIGNAL
Clinical Medicine

Investigation of the Prevalence of the HLA‐B*15:02 Allele in the Asian Populations: A Comprehensive Analysis Through Using AFND

Health Science Reports

Thailand-affiliated authors
Mohitosh Biswas · Maliheh Ershadian · Chonlaphat Sukasem
Institutions
Mahidol University · Ramathibodi Hospital · Bumrungrad International Hospital
75IMPACT SIGNAL
Clinical Medicine

Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease 2309676

The Journal of Immunology

Thailand-affiliated authors
Ayden Case · Jubayer Rahman
Institutions
National Institute of Health of Thailand
75IMPACT SIGNAL
Clinical Medicine

Prevention of recurrence of severe combined immunodeficiency through preimplantation genetic testing: a case study of a novel IL2RG variant and confirmed maternal somatic mosaicism in Thailand

Journal of Assisted Reproduction and Genetics

Thailand-affiliated authors
Napadon Yaibuates · Pongpet Benjaponwattana · Busarin Boonyacheeva · Jitti Saksantisuk
Institutions
Nakornthon Hospital · PTT Public Company Limited (Thailand)
75IMPACT SIGNAL
Clinical Medicine

From MyACR to MyμAlbumin: Clinical Validation of a High‐Precision, Real‐Time Immunoturbidimetric PoC Device for Early Chronic Kidney Disease Detection

Journal of Clinical Laboratory Analysis

Thailand-affiliated authors
Tullayakorn Plengsuriyakarn · Wanna Chai่jaroenkul · Napaporn Youngvises · Kridsada Sirisabhabhorn · Waraporn Bubpha · Kesara Na‐Bangchang
Institutions
Thammasat University · Thammasat University Hospital
75IMPACT SIGNAL
Clinical Medicine

Exosomal PD-L1 level in plasma as a predictive marker for prognostic and clinical correlation in NSCLC

Scientific Reports

Thailand-affiliated authors
Krisda Jitrakbumrung · Phuritat Sookananchai · Meena Tanapirakgul · Thutchima Khieota · Poorichaya Somparn · Trairak Pisitkun · Padet Tanangterapong · Panot Sainamthip
Institutions
Chulalongkorn University
75IMPACT SIGNAL
Clinical Medicine

From biological evidence to clinical application: a scoping review of oral fluid biomarkers in type 2 diabetic periodontitis

Frontiers in Oral Health

Thailand-affiliated authors
Sukumaran Anil
Institutions
Chulalongkorn University
75IMPACT SIGNAL
Clinical Medicine

Safety and Immunogenicity of an Additional Dose of Thailand Government Pharmaceutical Organization (GPO) Inactivated NDV-HXP-S COVID-19 Vaccine (HXP-GPOVac) Administered After Primary Vaccination with HXP-GPOVac or BNT162b2: An Open-Label Phase II Extension Trial in Thai Adults

Vaccines

Thailand-affiliated authors
Prabda Praphasiri · Darunee Ditsungneon · Anusak Kerdsin · Sutthichai Nakphook · Jiraphut Kittiwatanachod · Kanlaya Sornwong · Suriya Naosri · Sarunpattori Khunarsa · Ponthip Wirachwong · Isariya Techatanawat · Piengthong Narakorn · Somchaiya Surichan · Chakrarat Pittayawonganon · Sopon Iamsirithaworn · Supakit Sirilak · Kriengkrai Prasert
Institutions
Nakhon Phanom University · Kasetsart University · Sakon Nakhon Rajabhat University · Government of Thailand · Ministry of Public Health · Health Systems Research Institute
75IMPACT SIGNAL
Clinical Medicine

Depression, anxiety, and post-traumatic stress symptoms among wildland firefighters and local residents in recurrent wildfire areas

BMC Psychology

Thailand-affiliated authors
Kanthee Anantapong · Thitiworn Choosong · Siriporn Thaiyapongsakul · Thammasin Ingviya · Udomsak Saengow
Institutions
Prince of Songkla University · Walailak University
75IMPACT SIGNAL
Global Public Health

Treatment reliability of solar septic tank systems under comparative field conditions

Scientific Reports

Thailand-affiliated authors
Tatchai Pussayanavin · Thammarat Koottatep · Sopida Khamyai · Achara Taweesan · Rawintra Eamrat · Chongrak Polprasert
Institutions
Ramkhamhaeng University · Asian Institute of Technology · Thammasat University
75IMPACT SIGNAL
Clinical Medicine

From neuraminidase inhibitors to novel mechanisms: expanding therapeutic strategies against influenza

Frontiers in Cellular and Infection Microbiology

Thailand-affiliated authors
Yan Sun · Puongtip Kunanusorn · Kuang Ming Tup · Bing Yang
Institutions
Krirk University
75IMPACT SIGNAL
Clinical Medicine

Vibrio parahaemolyticusAHPND infection altered eicosanoid biosynthesis in the gastrointestinal tract of Litopenaeus vannamei

Biochemistry and Biophysics Reports

Thailand-affiliated authors
Wananit Wimuttisuk · Pisut Yotbuntueng · Pacharawan Deenarn · Punsa Tobwor · Surasak Jiemsup · Suganya Yongkiettrakul · Kamonluk Kittiwongpukdee · Siriwan Khidprasert · Chanadda Kasamechotchung · Kitlada Srichomthong · Phawit Putprasert
Institutions
National Science and Technology Development Agency · National Center for Genetic Engineering and Biotechnology · Mahidol University · Rajamangala University of Technology Tawan-ok · Thammasat University
75IMPACT SIGNAL
Clinical Medicine

Experimental and Computational Evaluation of Hybrid Bi2O3/WO3 Nanoparticle-Filled Epoxy Composites for Lead-Free Tc-99m Gamma-Ray Shielding in Occupational Radiation Protection

Polymers

Thailand-affiliated authors
Suphalak Khamruang Marshall · Phuchisa Tepnarin · Wuttipat Wattanaphonpinich · Waritthon Atsawasetthini
Institutions
Prince of Songkla University
75IMPACT SIGNAL
Multidisciplinary

Evidence of Crystallization from Amorphous VOx to VO2 (M1) Thin Film Investigated by in-situ LEEM and NEXAFS Techniques

Chiang Mai Journal of Science

Thailand-affiliated authors
Ukit Rittihong · Napatsakorn Sarapat · Thipusa Wongpinij · Chanan Euaruksakul · Saksorn Limwichean · Mati Horprathum · Prayoon Songsiriritthigul
Institutions
Suranaree University of Technology · Synchrotron Light Research Institute · National Electronics and Computer Technology Center
75IMPACT SIGNAL
Global Public Health

Seasonal transport, retention, and river-to-ocean transfer dynamics of floating macro-debris in the Umgeni River and estuarine lagoon, South Africa

Scientific Reports

Thailand-affiliated authors
Thomas Mani
Institutions
Chulalongkorn University
75IMPACT SIGNAL
Engineering

Characterizing Sensory Drivers of Acceptance, Purchase Intent, and Emotional Responses to Plant-Based Milk Alternatives in Chilled Sweetened Coffee Among Thai Consumers

Foods

Thailand-affiliated authors
Anh Luu Hoang Nguyen · Siriporn Siralertmukul · Sarisuk Sittiketgorn · Aussama Soontrunnarudrungsri · Suntaree Suwonsichon
Institutions
Kasetsart University
75IMPACT SIGNAL
Clinical Medicine

Multifunctional Bacillus Strains for Integrated Fruit Rot Management and Improved Soil Phosphorus Availability in Longan Orchards

Journal of Fungi

Thailand-affiliated authors
Pisi Suksakol · Chananbhorn Thongrote · Tatiya Bansra · Kanlayawat Intha · Jirapinya Liamkraituan · S. Mahadtanapuk
Institutions
University of Phayao · Ministry of Public Health · Kanchanaburi Rajabhat University
75IMPACT SIGNAL
Multidisciplinary

Effects of La2O3 on the Structure and Durability of Alkali Zirconium Silicate Glasses

Chiang Mai Journal of Science

Thailand-affiliated authors
Worapong Thiemsorn · Pinit Kidkhunthod · Nattapol Laorodphan · Ativit Denprawat
Institutions
Chiang Mai University · Synchrotron Light Research Institute · Maejo University
75IMPACT SIGNAL
Global Public Health

Remote Sensing Indices for Drought Characterization in Northeast Thailand: Provisional Descriptive Reference Points and Implications for Drought Monitoring

Sustainability

Thailand-affiliated authors
Narueset Prasertsri · Patiwat Littidej · Benjamabhorn Pumhirunroj
Institutions
Mahasarakham University · Sakon Nakhon Rajabhat University
75IMPACT SIGNAL
Environmental Engineering

Performance and Microstructure Evaluation of Lightweight Low-Heat Roof Tile Using Crushed Coconut Shell as Fine Aggregate

Journal of Materials in Civil Engineering

Thailand-affiliated authors
Tratnaphan Thiparphon · Apichat Suddeepong · Suksun Horpibulsuk · Kongsak Akkharawongwhatthana · Teerasak Yaowarat · Apinun Buritatum
Institutions
Suranaree University of Technology · The Royal College Of Anesthesiologists Of Thailand
EDITORIAL STANDARD

How we select research

We use OpenAlex, Crossref, PubMed, DOI records, and publisher pages, then verify Thai researcher participation before publication.

  1. 01Discover new researchFocus on the latest 90 days and verifiable Thai affiliations
  2. 02Assess signalsReview recency, quality, collaboration, and societal relevance
  3. 03Read with careReport findings with limitations and avoid claims beyond the evidence
  4. 04Open original sourcesEvery item includes a DOI, review date, and verification link