[(Bromomethyl)phenyl]methyl-Conjugated Chalcone Derivatives as Potential Lung Cancer Inhibitors: Structure Modification, Molecular Docking, Molecular Dynamics and In Vitro Validation
Researchers modified dimethyl cardamonin into derivatives 2a and 2b and evaluated them in lung-cancer cells, docking and molecular dynamics. Both inhibited NCI-H460 cells at IC50 values near 8 micromolar and were less toxic to MRC-5 cells than osimertinib in this assay, but direct EGFR-mediated action was not demonstrated.
Thai researchersNathaporn Cheechana · Nopawit Khamto · Kraikrit Utama · Chawanakorn Kongsak · Puracheth Rithchumpon · Padchanee Sangthong · Puttinan Meepowpan