The Synergistic Neuroprotective Effect of Honokiol and Magnolol Against Amyloid-β and MPP+-Induced Neurotoxicity in SH-SY5Y Cells: An Antioxidant, Molecular Orbital, and ADMET Study
Researchers tested honokiol, magnolol, and three mixture ratios in SH-SY5Y neuronal cells exposed to amyloid-β or MPP+-induced toxicity. Individual compounds at 0.1 μM and mixtures at 0.0001 μM significantly reduced intracellular reactive oxygen species. The mixtures showed synergistic effects in this model, but no animal or patient evidence is yet available.