A Comparative Analysis of the Action Mechanisms of Cannabidiol, Cannabigerol, and Cannabinol in Human Cholangiocarcinoma Cell Lines
Experiments in human cholangiocarcinoma cell lines KKU-100 and KKU-452 found dose- and time-dependent effects of cannabidiol, cannabigerol and cannabinol on viability, apoptosis, mitochondrial membrane potential and Ki67. Proteomics identified shared targets including LARP1 and TFEB. The work generates mechanisms, not patient-treatment evidence, and does not support self-medication with cannabis products.