Gut microbiome modulation by Veillonella ratti induces resistance to EAE pathogenesis via microbe-derived metabolites
In a mouse experimental autoimmune encephalomyelitis model, infant-derived Veillonella ratti MHL0042 reshaped gut microbiota, reduced CD4+ IFN-gamma T cells and lowered activated spinal-cord microglia. The proposed mechanism involves depletion of pldA-containing bacteria and increased dioleoyl phosphatidylethanolamine (DOPE) in the gut, circulation and central nervous system. Exogenous DOPE reproduced attenuation of disease and microglial activation.