Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection
Two randomized controlled phase 3 trials are investigating the antisense oligonucleotide drug bepirovirsen in patients with chronic hepatitis B. with researchers from Chiang Mai University co-authoring
Paired samples from treatment-naïve gastric-cancer patients and controls showed substantially higher richness and diversity with mucosal brushing than biopsy. Brushing detected lower diversity and altered composition in cancer, whereas biopsy did not. Sampling method shapes microbiome signals, but causation and diagnostic utility are unproven.
Gizzard lesions in Thai chickens contained intranuclear inclusions, in-situ hybridization signal and PCR-confirmed fowl adenovirus. Hexon and fibre sequencing identified FAdV-8a strain FAdV8a_NPT_KU001_25, closer to a gizzard-tropic than an inclusion-body-hepatitis strain. Association is supported, but causation remains unproven.
A two-clinic Chiang Mai study of 150 MSM and transgender women found clinically significant depression in 5.3% of PrEP users and 13.3% of non-users. Mean depression was lower among PrEP users, while suicidal ideation occurred in 5.3% with no group difference.
An exploratory case-control study of 37 Thai adults with confirmed beta-lactam hypersensitivity identified HLA-DQA1*01:04 and HLA-DQA1*05:05 candidate signals after Bonferroni correction, with the latter stronger for immediate reactions. Small size, population controls and sensitivity-instability mean the findings are not ready for screening or drug avoidance.
Twenty male esports players were randomised to cup stacking three days weekly for four weeks or usual training. Post-intervention salivary alpha-amylase fell within the experimental group and differed significantly from controls.
Giant freshwater prawns received control diets or 10% and 20% fishmeal replacement with L. plantarum TISTR1284-fermented Leucaena for two weeks. Fermented diets increased immune markers and reduced post-A. hydrophila mortality by 26.14%, with normal intestinal morphology.
The systematic review identified 17 reports representing 15 randomised trials with 6,256 participants; 2,216 contributed to overweight subgroup analyses. The meta-analysis included 12 studies and 1,728 pregnant women with overweight. Interventions combined diet and physical activity, often with goal setting, self-monitoring and digital or remote follow-up.
A seven-country prospective cohort of 1,703 adults with HIV found Mycobacterium tuberculosis bloodstream infection predominantly among inpatients and associated it with higher 30-day mortality.
An evaluation of 1,838 stored sera from seven countries found that a second-generation Hcp1 antibody test had sensitivity ranging from 48% to 92%, with specificity varying by country and comparison group.
Thai researchersHasyanee Binmaeil · Thanakon Bunsong · Mary N. Burtnick · Paul J. Brett · Narisara Chantratita
Analysis of Thai national claims from 2015–2023 identified 60,916 paediatric hepatobiliary admissions. Admission rates were broadly stable and in-hospital mortality declined, while hepatic failure remained a high-risk condition.
An international expert statement spanning 22 countries reviews links among food systems, cardiometabolic health and the Sustainable Development Goals. It advocates plant-forward traditional diets rich in whole grains, legumes, vegetables, fruit, nuts and spices, with meat used sparingly.
The multicentre survey analysed 604 patients from 25 Thai hospitals between December 2023 and March 2024. SSRIs accounted for 70.2% of prescriptions, followed by TCAs at 13.9% and trazodone at 12.7%. The most common diagnoses were depressive disorders (55.0%), substance use disorders (15.2%) and psychotic disorders (13.7%). Clinicians cited limited availability (21.9%), reimbursement arrangements (36.3%) and patient finances (33.9%) as prescribing constraints.
Thailand-affiliated bibliographic records. These are not full analyses; they are ordered by Impact Signal and should be verified against the original source.
3,510records
3,510 records
70IMPACT SIGNAL
Global Public Health
Isolate-Specific Modulation of Growth, Carbon Allocation, and Transcriptomic Responses in Spirodela polyrhiza by Duckweed-Associated Bacteria
Microorganisms
Thailand-affiliated authors
Arinthip Thamchaipenet · Masaaki Morikawa
Institutions
Kasetsart University
70IMPACT SIGNAL
Multidisciplinary
Comparative Dermatological Bioactivities of Chlorophylized and Dechlorophylized Centella asiatica Extracts
Evaluation of Inhibitory Activities of Phenolic and Flavonoid Constituents of Nelumbo nucifera Gaertn. Against Tyrosinase, Elastase, and Collagenase by Computational Methods and Supported by Experimental Validation
Numerical Analysis of First- and Second-Law Performance in Round Tubes Equipped with Multiple Helical Screw Tape Inserts
Eng—Advances in Engineering
Thailand-affiliated authors
Smith Eiamsa‐ard · Sathaporn Liengsirikul · S. Chokphoemphun · Varesa Chuwattanakul · Paisan Naphon · Monsak Pimsarn
Institutions
Mahanakorn University of Technology · Kasetsart University · Sakon Nakhon Rajabhat University · King Mongkut's Institute of Technology Ladkrabang · Srinakharinwirot University
70IMPACT SIGNAL
Global Public Health
Maternal ontogeny modulates auxin-associated cutting mortality in Amentotaxus formosana, with genotype-specific responses revealed by Cox proportional hazards modelling
Frontiers in Plant Science
Thailand-affiliated authors
Meng‐Shin Shiao
Institutions
Ramathibodi Hospital
70IMPACT SIGNAL
Clinical Medicine
Spatial Determinants of Pathogenic Leptospira Viability in Paddy Field Surface Waters: Mechanistic Insights from Machine Learning and Geographically Weighted Logistic Regression
Depressive Symptoms Among Orphaned University Students in Thailand: The Role of Attachment Insecurity, Resilience, Inner Strength, and Perceived Social Support
