Metabolomic Alterations Associated with Adjunctive Hydrogen Gas Inhalation During Concurrent Chemoradiotherapy in Locally Advanced Head and Neck Cancer: A Pilot Study
A randomised pilot trial in 20 patients with locally advanced head-and-neck cancer compared standard concurrent chemoradiotherapy with added hydrogen inhalation and explored pre-post metabolomics. Moderate toxicities and treatment delays were numerically fewer with hydrogen, but differences were not significant and only 19 participants were evaluable.