Metal–Organic Framework Composite Piezoelectric Nanofibers for Wireless Tumor Treating Fields Therapy
Mn-Ti bimetallic MOF was incorporated into electrospun polyacrylonitrile nanofibers to generate localized electric fields under mechanical stimulation. Ultrasound produced a reported 0.35-V output, accompanied by alternating fields, tumor-cell apoptosis and good compatibility with normal cells. In vivo experiments suppressed glioblastoma growth. The concept remains preclinical and requires long-term implant safety and treatment-control studies.