Effectiveness and safety of 7-day high-dose primaquine and single-dose tafenoquine versus 14-day low-dose primaquine in patients with Plasmodium vivax malaria (EFFORT): a multicentre, open-label, randomised, controlled, superiority trial
The multicountry EFFORT trial compares shorter radical-cure strategies under unsupervised, real-world use in people meeting a G6PD activity threshold. Its practical value lies in balancing recurrence prevention and adherence against haemolysis risk rather than treating convenience as the only outcome.